Marquette handed No. 9 Syracuse their fourth straight loss on Saturday afternoon.
Jae Crowder scored 13 of his 25 points in the second half to lead the Golden Eagles to a 76-70 victory.
The Orange have lost four in a row for the first time since Jan. 16-29, 2006.
Syracuse had won five straight over Marquette since it joined the conference in 2005 and held a 7-2 all-time record coming into the game.